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Remove Running Headers and Footers when it is identical or consistent on every page. To delete a running header see Regex and/or ask Sabina.
Keep information that is unique to a page, such as footnotes. For example, on this page keep the Footnote, but remove the Running Header.
When editing a document converted from a PDF, headers and footers should have a regular pattern, allowing you to replace them with paragraph breaks (if page numbering is irrelevant) or page breaks (if page numbering is to be conserved).
Again, please see the regular expressions section for more information.